TABLE 1.

Vaccination with rLP2086 induces strong systemic immune responses in micea

Antigen (amt)Adjuvant (amt)Titer
IgG (mean log10 ± SD)IgG1IgG2aIgG2bIgG3IgA
rLP2086 (5 μg)None5.94 ± 0.03337,216172,699101,596674106
rLP2086 (5 μg)CT-E29H (10 μg)6.19 ± 0.31404,055453,147327,2941,19583
  • a Swiss Webster mice (10/group) were vaccinated s.c. at weeks 0 and 4 and bled at week 6. The IgG antibody titers against rLP2086 were determined by ELISA of individual serum samples collected at week 6. The IgG subclass and IgA antibody titers against rLP2086 were determined by ELISA on pooled sera collected at week 6.