TABLE 2.

Serum IgG antibodies elicited by rLP2086 cross-reacted to multiple meningococcal strainsa

Antigen (amt)Adjuvant (amt)Test strainb
8529H44/76H355880049M982870227870446CDC1521
rLP2086 (5 μg)None5.03 ± 0.224.72 ± 0.154.47 ± 0.174.06 ± 0.123.72 ± 0.144.82 ± 0.184.16 ± 0.123.59 ± 0.13
rLP2086 (5 μg)CT-E29H (10 μg)5.20 ± 0.264.96 ± 0.234.62 ± 0.273.78 ± 0.373.86 ± 0.224.92 ± 0.283.76 ± 0.543.39 ± 0.21
  • a Swiss Webster mice (10/group) were vaccinated s.c. at weeks 0 and 4 and bled at week 6. The geometric mean serum IgG titers against whole cells of various meningococcal strains were determined by ELISA of individual serum samples collected at week 6 and reported as log10 ELISA titers ± standard deviation.

  • b All strains belong to P2086 subfamily B, except strains 870446 and CDC1521.