TABLE 1.

Antigen-specific immune response and antigen distribution in NALT following nasal immunization

AdjuvantAntigenPlasma IgGaS-IgAbT helper activityTT in NALTcReference(s)
TT+d+Th1/Th2++++30,47,51
nCTTT+++++++Th2+47,50,51
mCT(E112K)TT+++++++Th2++50,51
nLTh-1TT+++++++Th1/Th2++++2,7, 42
mLTh-1(E112K)TT+++++++Th1/Th2++++2,7
LTIIbAgI/IIe+++++++Th1/Th2++++34
  • a IgG, immunoglobulin G.

  • b S-IgA, mucosally-derived secretory IgA.

  • c Data were obtained in this study and indicate the relative TT antigen accumulation in NALT.

  • d +, low-, ++, medium-; +++, high-; ++++, very high.

  • e AgI/II, Antigen I/II from Streptococcus mutants.