TABLE 3.

Comparison of the lethality of ica-complemented and Δica strains of S. aureus following i.p. injection into FVB mice

StrainNo. of survivors/total no. of challenged mice (%) (challenge dose per mouse)aP valueb
ica-complemented strainΔica mutant
Mn80/6 (0) (5.0 × 108)5/6 (83.3) (5.0 × 108)0.008
Newman0/6 (0) (4.3 × 108)6/6 (100) (6.7 × 108)0.001
108331/8 (12.5) (1.0 × 109)8/8 (100) (1.0 × 109)0.0007
  • a Challenge dose in CFU per mouse.

  • b P value by Fisher's exact test.