TABLE 5.

Growth of virulent strain FSC033 in organs of control mice and mice vaccinated with LVS or FSC043a

Immunizing strainFrancisella burden on day 3 of infection (mean log10 CFU ± SD)b
LungsLiverSpleen
None5.18 ± 2.037.49 ± 0.868.33 ± 1.13
LVS<1.30 (0/3)2.91 ± 0.413.62 ± 0.25
FSC043<1.30 (0/3)<2.25 (1/3)2.63 ± 1.74
  • a Mice (n = 3/group) immunized i.d. 120 days earlier with 106 CFU of LVS or FSC043 were challenged by the same route with 150 CFU of F. tularensis type A strain FSC033. Mice were killed on day 3 of infection, and Francisella burdens in livers, spleens, and lungs were determined.

  • b Numbers in parentheses show the proportion of organs infected.