TABLE 4.

Results of fertility studies

AntigenAdjuvantNo. of mice that had embryos in uterine horns/total no. of mice/group (%)Mean no. of embryos in uterine horns ± 1 SD
BothRightLeftaBothRightLefta
MOMPCpG + Montanide15/20 (75)c,e20/20 (100)15/20 (75)c,e5.7 ± 3.0d,f3.1 ± 1.42.6 ± 2.4d,f
OvalbuminCpG + Montanide2/20 (10)14/20 (70)2/20 (10)3.0 ± 2.52.9 ± 2.40.2 ± 0.5
MOMPCpG + alum7/20 (35)17/20 (85)8/20 (40)4.2 ± 2.2d,f3.3 ± 1.90.9 ± 1.3
OvalbuminCpG + alum2/20 (10)12/20 (60)2/20 (10)2.3 ± 2.42.0 ± 2.10.3 ± 0.8
C. trachomatis17/21 (81)c,e20/21 (95)18/21 (86)c,e5.7 ± 2.6d,f3.1 ± 1.72.6 ± 1.5d,f
MEM-06/20 (30)16/20 (80)7/20 (35)3.7 ± 2.13.0 ± 2.00.8 ± 1.2
Fertility controlb20/24 (83)23/24 (96)21/24 (88)5.8 ± 2.53.2 ± 1.62.7 ± 1.8
  • a Ovarian bursae inoculated with C. trachomatis MoPn.

  • b Fertility control: mice were neither immunized nor challenged.

  • c P < 0.05 by the Fisher exact test, compared to the corresponding ovalbumin- or MEM-0-immunized control group.

  • d P < 0.05 by the Mann-Whitney U test, compared to the corresponding ovalbumin- or MEM-0-immunized control group.

  • e P > 0.05 by the Fisher exact test, compared to the fertility control group.

  • f P > 0.05 by the Mann-Whitney U test, compared to the fertility control group.