TABLE 3.

Results of vaginal cultures

Mice immunized with:AdjuvantNo. of mice that sheda and no. of C. trachomatis IFU shedbTotal no. of mice that shed in 6 wk (% positive)
wk 1wk 2wk 3wk 4wk 5
Mice sheddingC. trachomatis IFU shedMice sheddingC. trachomatis IFU shedMice sheddingC. trachomatis IFU shedMice sheddingC. trachomatis IFU shedMice sheddingC. trachomatis IFU shed
MOMPCpG + Montanide1/20 (5)c0 (0-960)d2/20 (10)c0 (0-12)d0/20 (0)00/20 (0)00/20 (0)03/20 (15)c
OvalbuminCpG + Montanide12/20 (60)2 (0-2,368,060)13/20 (65)14 (0-534,586)5/20 (25)0 (0-134,720)1/20 (5)0 (0-6)0/20 (0)017/20 (85)
MOMPCpG + alum7/20 (35)c0 (0-36,868)d10/20 (50)c13 (0-2,272)d4/20 (20)0 (0-1,160)0/20 (0)00/20 (0)015/20 (75)
OvalbuminCpG + alum13/20 (65)18 (0-891,922)17/20 (85)391 (0-302,034)5/20 (25)0 (0-309,124)1/20 (5)0 (0-7,820)0/20 (0)019/20 (95)
C. trachomatis3/21 (14)c0 (0-18)d0/21 (0)c0d0/21 (0)00/21 (0)00/21 (0)03/21 (14)c
MEM-011/20 (55)2 (0-8,500)10/20 (50)327 (0-372,934)1/20 (5)0 (0-2,380)1/20 (5)0 (0-867)0/20 (0)015/20 (75)
  • a No. of mice that shed/total no. of mice per group (% positive).

  • b Median no. of C. trachomatis IFU shed per group (range).

  • c P < 0.05 by the Fisher exact test, compared with the corresponding ovalbumin- or MEM-0-immunized control group.

  • d P < 0.05 by the Mann-Whitney U test, compared with the corresponding ovalbumin- or MEM-0-immunized control group.