TABLE 2

In vivo virulence levels of Tat substrate mutations

GenotypeMean CINo. of miceP valuea
tatC::cml>0.00010751040.0228
sufI::cml>0.00000640440.0228
ybtP::cml0.016 ± 0.02550.0265
yedY::cml0.688 ± 0.458100.0463
YPTB3074::cml0.546 ± 0.764110.0206
urtA::cml0.663 ± 0.698100.0361
amiC::cml2.078 ± 3.0467NS
efeB::cml6.132 ± 2.3075NS
pepP::cml1.73 ± 2.17610NS
fhuD::cml1.75 ± 1.6164NS
nicO::cml0.95 ± 0.4034NS
dmsA::cml2.847 ± 5.77011NS
napA::cml6.393 ± 9.8466NS
dmsA2::cml2.301 ± 3.8748NS
tauA::cml0.827 ± 0.6298NS
YPTB2692::cml2.737 ± 3.7934NS
YPTB0523::cml2.397 ± 1.2014NS
fdoG::cml1.07 ± 0.5497NS
cueO::cml5.047 ± 3.2664NS
ΔcynT::cml5.696 ± 3.1824NS
ΔycbK::cml6.772 ± 11.3467NS
ΔYPTB3260::cml4.7 ± 2.9614NS
ΔYPTB1325::cml4.182 ± 4.0304NS
  • a The Mann-Whitney U test, one-way ANOVA, and Student's t test were used to analyze differences. NS, no significant difference.