Table 1.

The MR does not regulate O2 production in human MDMsa

TreatmentaConditionsMean O2 production (nmol/106cells) ± SEMb
BSA latex beadsPBS0.34 ± 0.12 (3c)
Trimannoside-BSA latex beadsPBS0.92 ± 0.21 (2)
Opsonized zymosanPBS19.75 ± 2.10 (3)
Opsonized zymosanMan-BSA22.07 ± 3.15 (3)
PMAPBS10.70 ± 3.00 (4)
PHAMannan12.07 ± 3.12 (4)
  • a MDMs were exposed to BSA-latex beads or trimannoside-BSA latex beads (50 particles per cell) for 60 min, to opsonized zymosan (50 particles per cell) for 30 min, or to PMA (1 μg/ml) for 30 min. In some experiments, MDMs were preincubated with mannan (3 mg/ml) or Man-BSA (200 μg/ml).

  • b O2 generation over the basal production.

  • c Number of independent experiments.