Table 2.

Infant rat model of meningococcal infection

ParameterMC582120
Wild typelstgalEWild typelstgalE
Infective dose [log10(CFU)/ animal]6.326.375.586.676.496.66
n984774
Log10(CFU)/ ml of blooda 4.97 ± 0.284.80 ± 0.29<1.04.63 ± 0.703.39 ± 0.49<1.0
Pb 0.250.002
  • a The limit of detection was 1.0 CFU/ml of blood.

  • b Log10(CFU)/ml of blood values were compared by Student’s t test. Differences were considered significant at P of <0.01.