Table 2.

Nonopsonic phagocytosis of pathogenic and nonpathogenic mycobacteria does not stimulate the production of O2 in MDMs

TreatmentaMean ± SEM (no. of independent experiments)
Phagocytic cells (%)bO2 production (nmol/106 cells)c
Zymosan36 ± 3 (11)17.77 ± 5.44 (8)
M. phlei 36 ± 3 (8)−1.75 ± 2.63 (8)
M. smegmatis 33 ± 4 (11)0.33 ± 2.12 (6)
M. kansasii 32 ± 3 (11)1.66 ± 3.19 (3)
  • a MDMs were exposed to zymosan for 30 min or mycobacteria for 60 min at a particle-to-cell ratio of 50:1.

  • b Percentage of cells having internalized at least one particle.

  • c O2 generation over the basal production.