TABLE 1

Peripheral blood cell populations

PopulationMedian count (IQR)P valued
PreinfectionPeak parasitemia24 h posttreatmentPre c/-peak parasitemiaPre c/-posttreatment
Parasite genomes (genomes/ml whole blood)031,395 (22,119–89,145)94 (6–112)NANA
Platelets (109/liter)209 (1,188–231)159 (136–179)113 (78–139)a0.03NS
Granulocytes (109/liter)2.5 (2.1–5.3)2.8 (1.8–4.3)1.5 (1.4–5.3)bNSNS
Monocytes (109/liter)0.6 (0.4–1.4)0.3 (0.2–0.4)0.2 (0.1–0.4)bNSNS
Lymphocytes (109/liter)1.7 (1.6–1.9)0.8 (0.3–1.1)0.6 (0.6–0.7)b0.030.06
PBMCc (109/liter)2.4 (2.0–2.9)1.1 (0.6–1.4)0.8 (0.7–1.0)b0.030.06
CD14+ cells (cells/μl)55 (40–72)22 (6–37)9 (3–17)b0.060.06
B cells (cells/μl)183 (137–338)96 (30–206)65 (33–110)b0.030.06
NK cells (cells/μl)86 (79–111)10 (5–15)16 (12–41)b0.030.06
CD4+ T cells (cells/μl)722 (604–938)410 (194–527)318 (279–381)b0.030.06
CD8+ T cells (cells/μl)137 (106–184)81 (26–104)19 (13–87)b0.060.06
Treg (cells/μl)46 (33–59)32 (12–36)a18 (14–21)aNSNS
  • a n = 4.

  • b n = 5.

  • c PBMC, peripheral blood mononuclear cells.

  • d c/-, compared to; NA, not applicable; NS, not significant.