Table 2.

Volunteer symptoms and immune responses against S. flexneri 2a LPS or Ipa elicited by a 2 × 106-CFU dose of SC602 vaccine

VolunteerSymptomsPeakano. of ASC/106 PBL anti-LPSFold increasea in serum anti-LPS concnUrine anti-LPSb (IgA)Serum anti-Ipab (IgA or IgG)
Fever temp (°F)Diarrhea vol (ml)IgAIgGIgAIgGIgM
C011<1<1
P81<1<1<1
D6171151<1<1
B101.95716104<1<1++
M1057122<1++
A1328062<1+
J5922496032<1+
K101.33059234<1+
E103.72534061461043++
N506479374<1<1+
L101.362141643<1+
G102.61,354706158423+
W1,185916287934+
H1,1091085<1<1+
R1,2087622072+
  • a ASC levels peaked on day 7 and ELISA titers peaked on day 14.

  • b +, positive response of ≥4-fold increase over baseline; −, negative response.