Table 1.

Statistical comparison of the numbers of mice surviving mice i.p. administration of a mixture of MAb and organismsa

Mouse-treatment combinationP for comparison with:
C3-PBSC4-PBSF2-PBSC3-IgMC4-IgMF2-IgMC3-D11C4-D11
C4-PBS0.06
F2-PBS0.16 0.01
C3-IgM0.39 9 × 10−3 0.45
C4-IgM0.68 0.01 0.300.63
F2-IgM0.18 5 × 10−3 0.610.650.37
C3-D110.090.72 0.02 0.02 0.03 9 × 10−3
C4-D11 2 × 10−4 3 × 10−4 2 × 10−4 2 × 10−4 1 × 10−4 2 × 10−4 1 × 10−4
F2-D11 2 × 10−4 3 × 10−4 5 × 10−4 2 × 10−4 1 × 10−4 2 × 10−4 1 × 10−4 0.9566
  • a Mice with targeted deletions of C3 and C4 and F2 control mice were either treated with MAb D11 or a control IgM or left untreated. P values were determined by the Kaplan-Meier log rank survival test. Statistically significant values are shown in boldface type.