Table 3.

Antibody levels to N. gonorrhoeae MS11 in serum and genital secretions from noninfected and infected female patients

SampleMedian antibody level (ng/ml) (range)
Visit 1Visit 2
Noninfected (n = 30)N. gonorrhoeae infected (n = 17)Noninfected (n = 15)N. gonorrhoeae infected (n = 13)
Cervical mucus
 IgA10 (0–196)0 (0–326)0 (0–174)0 (0–119)
 IgA20 (0–27)a 0 (0–0)0 (0–0)0 (0–0)
 IgG850 (0–12,034)1,188 (0–15,600)556 (0–7,895)1,000 (0–9,810)
 IgM0 (0–2,936)0 (0–2,632)0 (0–4,655)242 (0–2,775)
Vaginal wash
 IgA10 (0–212)0 (0–40)0 (0–30)6 (0–55)
 IgA20 (0–0)0 (0–94)a 0 (0–0)0 (0–0)
 IgG66 (0–671)81 (0–12,143)91 (0–619)96 (0–1,319)
 IgM0 (0–66)0 (0–85)0 (0–174)0 (0–782)
Serum
 IgA1122 (16–923)413d (137–1,817)249 (83–380)397d (65–2,725)
 IgA20 (0–751)b 0 (0–136)c 0 (0–145)a 0 (0–3,417)a
 IgG27,800 (11,000–82,700)21,655 (10,316–71,234)22,140 (11,200–52,716)26,780 (8,551–65,433)
 IgM19,650 (0–90,000)19,990 (10,230–40,700)13,100 (3,450–29,190)21,387 (4,710–61,935)
  • a One patient was positive for IgA2 antibodies.

  • b Three patients were positive for IgA2 antibodies.

  • c Five patients were positive for IgA2 antibodies.

  • d P < 0.05 compared with noninfected subjects at same time (Mann-Whitney U test).