Table 2.

Statistical comparison of the numbers of mice surviving i.p. administration of MAb followed in 1 h by infectiona

Mouse-treatment combinationP for comparison with:
C3-PBSC4-PBSC3-IgMC4-IgMC3-D11
C4-PBS 0.02
C3-IgM1.0 0.02
C4-IgM0.550.130.55
C3-D110.130.240.130.48
C4-D11 1 × 10−4 3 × 10−4 1 × 10−4 1 × 10−4 1 × 10−4
  • a Mice with targeted deletions of C3 and C4 and F2 control mice were either treated with MAb D11 or a control IgM or left untreated. P values were determined by the Kaplan-Meier log rank survival test. Statistically significant values are shown in boldface type.