Table 1.

Type-specific antibodies in sera after immunization with PPS and PNC

TypeVaccine (dose [μg])RouteAdjuvantGeometric mean titer (EU/ml)a of:
IgGIgMIgA
Type 1
 APNC-1 (0.5)i.n.RV771 (384–1550)40 (26–62)42 (29–62)
 BPNC-1 (2.0)i.n.RV5,365 (2,720–10,583)55 (33–91)341 (207–564)
 CPPS-1 (2.0)i.n.RV38 (11–125)71 (47–106)52 (37–72)
 DPNC-1 (0.5)i.n.Saline33 (15–74)11 (5–24)26 (21–33)
 EPNC-1 (2.0)i.n.Saline220 (132–371)23 (13–43)49 (28–85)
 FPPS-1 (2.0)i.n.Saline7 (5–11)33 (22–48)45 (28–72)
 GPNC-1 (0.5)s.c.Saline2,562 (882–7,441)99 (31–312)62 (40–95)
 HControl3 (3–4)17 (10–28)28 (20–42)
Type 3
 APNC-3 (2.0)i.n.RV48 (12–193)68 (50–92)
 BPPS-3 (2.0)i.n.RV5 (4–6)49 (34–70)
 CPNC-3 (2.0)i.n.Saline3 (1–6)37 (15–78)
 DPPS-3 (2.0)i.n.Saline4 (3–8)44 (16–121)
 EPNC-3 (2.0)i.p.FCA or FIA1,650 (1,131–2,407)147 (67–327)
 FControl2 (2–3)38 (15–97)
  • a The 95% confidence interval is given in parentheses.