Table 2.

Passive protection of BALB/c mice conferred by MAb Me-7 against infection with N. meningitidis 608B or 164Ba

Challenge strain (serological classification)GroupNo. of living mice at 72 h after the bacterial challenge/total no.% Survival
608B (2a:P1.2:L3)400 μl of ascitic fluid containing MAb Me-77/1070
600 μg of MAb Me-712/1580
400 μg of MAb Me-78/1080
400 μl of ascitic fluid containing P2-4 or PBS4/1526
164B (B:15:P1.7,1.6)400 μl of ascitic fluid containing MAb Me-712/12100
400 μl of PBS3/1225
  • a The MAbs or phosphate-buffered saline (PBS) was administered intraperitoneally 18 h before challenge. The mice were then challenged with 1 ml of a meningococcal suspension containing 4% mucin and 1.6% hemoglobin. The meningococcal strains 608B and 164B were adjusted to 1,500 and 1,000 CFU/ml, respectively, and 1 ml of the bacterial suspension was injected intraperitoneally into each mouse.