Table 3.

Histopathology data showing mean inflammatory scores of kidney, placental, and fetal tissues of E. coliDr+- and E. coli Dr-infected and control mice

GroupaInflammatory score (mean ± SEM) in tissueb
KidneyPlacental tissueFetal tissue
Renal pelvisTubular involvementInterstitial involvement
AcuteChronicAcuteChronicAcuteChronic
Sacrificed after delivery
E. coliDr+ 2.12 ± 0.44c 1.50 ± 0.32c 0.62 ± 0.4101.62 ± 0.321.12 ± 0.512.37 ± 0.32d 3.25 ± 0.25d
E. coliDr 0.25 ± 0.160.25 ± 0.2500000.62 ± 0.260.50 ± 0.26
 Control00000000
Sacrificed on day 17 of gestation
E. coliDr+ 0.75 ± 0.25e 1.87 ± 0.35e 000.25 ± 0.16e 0.37 ± 0.18e ND0.66 ± 0.42
E. coliDr 0.62 ± 0.411.25 ± 0.16000.12 ± 0.120.37 ± 0.26ND0
 Control000000ND0
  • a Histopathology results in mice sacrificed after delivery were obtained from eight mice in eachE. coli Dr+ and E. coliDr group and six mice in the control group. Group sacrificed on day 17 of gestation included eight mice in the E. coli Dr+ group, eight mice in the E. coliDr group, and five mice in the control group.

  • b Histopathologic evaluation was performed and scores were given as described in Materials and Methods under “Histological analysis of tissues.” ND, not determined.

  • c Significantly different from the value obtained for the E. coli Dr group (P ≤ 0.001).

  • d Significantly different from the value obtained for the E. coli Dr group (P ≤ 0.0001).

  • e Not significantly different from the value obtained for the E. coli Dr group (P > 0.05).