Table 2.

Quantitative bacterial tissue cultures and determination of fetal birth weight outcome in infected and control groups of C3H/HeJ mice

GroupMean no. (CFU/g) of bacteria ± SEM found by bacterial cultureMean fetal wtb (g) ± SEM (no. of fetuses)
After deliveryaAt day 17 of gestationb
KidneyFetusSpleenKidneyFetusSpleen
E. coliDr+ 5 × 108 ± 1 × 108 c 3 × 108 ± 2 × 108 d ND8 × 109 ± 2 × 109 e 4 × 109 ± 2 × 109 f >108 e (4/8)g 0.644 ± 0.030h (6)
E. coliDr 5 × 107 ± 2 × 107 7 × 106 ± 7 × 106 ND5 × 109 ± 2 × 109 1 × 107 ± 1 × 107 >108 (2/8)0.813 ± 0.021 (6)
Control00ND0000.88 ± 0.10 (5)
  • a Day 7 E. coli-infected and control groups of mice were sacrificed after the delivery, and tissues were collected for E. coli bacterial cultures. These data were obtained from 10 mice in the E. coli Dr+group and 12 mice in the E. coli Dr group and 6 mice in the control group. ND, not determined.

  • b Day 7 E. coli-infected and control groups of mice were sacrificed on day 17 of gestation, tissues were collected for bacterial cultures, and fetuses were removed and carefully weighed for each group of mice. This experiment included eight mice in each E. coli Dr+ or E. coli Dr group and five mice in the control group.

  • c Significantly different from the value obtained for the E. coli Dr group (P = 0.004).

  • d Significantly different from the value obtained for the E. coli Dr group (P = 0.02).

  • e Not significantly different from the value obtained for the E. coli Dr group (P > 0.05).

  • f Significantly different from the value obtained for the E. coli Dr group (P = 0.05).

  • g The number of mice with >108 CFU per g of spleen to the total number of mice in the group is shown in the parentheses (P > 0.05).

  • h Significantly different from the values obtained for the E. coli Dr and control groups (P = 0.003).