Table 4.

Effect of vaccination with PS14TT vaccine on standard middle ear challenge with histamine and Pn 14 (infection rate and Pn-specific serum IgG titers)

Infection rate or IgG titerPBS (sham)PS14TTn (both groups)
Infection rate72.2%27.8%b24
α PS 14 IgGa0.0 ± 0.01.87 ± 0.17c18
α CPS IgGa−0.13 ± 0.070.26 ± 0.20c18
  • a IgG serum titers are the means of differences ± standard errors of the means between the values before (day 0) and after vaccination (day 35); nonresponders are included. IgG titers are presented as log10 dilution at 50% maximum optical density.

  • b Significantly different (P < 0.05) from values in sham-treated groups as calculated by a Fisher's exact test.

  • c Significantly different (P < 0.05) from values in sham-treated groups as calculated by a Student's t test.