Table 3.

Impact of repeated CpG ODN administration on survival after rechallengea

RxChallengeRechallengeNo. surviving/no. challenged% Survival
PBSL. monocytogenes0/100
F. tularensis1/1010
CpG ODNL. monocytogenes20/20100
F. tularensis10/10100
CpG ODNL. monocytogenesL. monocytogenes10/10100
L. monocytogenesF. tularensis0/100
  • a BALB/c mice were injected i.p. with PBS or 50 μg of CpG ODN every 2 weeks for 2 months (five injections). One to 14 days after the last injection, the animals were challenged with 103 LD50 of L. monocytogenes orF. tularensis. The mice that survived L. monocytogenes challenge were then rechallenged 45 days later (after the cessation of CpG ODN therapy). The data show the number (and percentage) of mice surviving >3 weeks postchallenge. Rx, treatment.