Table 2.

Activity of cationic antimicrobial peptides against gram-positive bacteria and E. colia

StrainMIC (μg/ml)b
CP26CEMECEMACP29CP203CP207CP208CM5CM7CPα2PBc
S. aureus
 RN422064448816>646441632
 25923>6488161632>64>64161632
 SAP0017 (MRSAe)644416816>64>6481632
 Clinical isolate>6481616816>64>64161616
 Clinical isolate>6441616816>64>64163216
S. epidermidis 1644848>643281616
S. pyogenes196151688848>64168168
E. faecalis29212>643232643264>64>641664>64
B. subtilis 328881616>646481664
L. monocytogenes 32444486464484
C. xerosis 244422324442
E. coliUB1005d 122222325220.5
  • a Bacterial strains were cultured with serial twofold dilutions of the various peptides (0.5 to 64 μg/ml) for 18 h as described in Materials and Methods.

  • b The MIC represents the minimal concentration of peptide that completely inhibited growth. The values represent the averages of data from three experiments.

  • c PB, polymyxin B.

  • d MICs for this organism were taken from reference 22.

  • e MRSA, methicillin-resistant S. aureus.