Table 2.

Systemic complaints reported in a standardized diary within 7 days following each inoculation with C. difficiletoxoid vaccine, by dose and formulation

Complaint	No. of subjects^awho received:
	6.25 μg of toxoid		25 μg of toxoid		100 μg of toxoid
	Toxoid	Toxoid-alum	Toxoid	Toxoid-alum	Toxoid	Toxoid-alum
Anorexia	1	0	0	0	1	1
Malaise	2	0	0	2	1	0
Joint swelling	0	0	0	0	0	1
Numbness	1	0	0	0	1	1
Rash	1	2	0	2	2^b	1^b
Abdominal pain	1^c	1	1	0	2	1
Joint pain	0	1	0	1	0	0
Fever	0	0	0	0	0	0
Diarrhea	1^c	0	0	0	1^b	0
Any of the above	3	2	1	3	2	2

↵a There were five subjects in each treatment group.
↵b It should be noted that one subject in each group experienced two episodes of the specified complaint (after different inoculations).
↵c This subject experienced three episodes of the specified complaint (after different inoculations).