Table 2.

Systemic complaints reported in a standardized diary within 7 days following each inoculation with C. difficiletoxoid vaccine, by dose and formulation

ComplaintNo. of subjectsawho received:
6.25 μg of toxoid25 μg of toxoid100 μg of toxoid
ToxoidToxoid-alumToxoidToxoid-alumToxoidToxoid-alum
Anorexia100011
Malaise200210
Joint swelling000001
Numbness100011
Rash12022b 1b
Abdominal pain1c 11021
Joint pain010100
Fever000000
Diarrhea1c 0001b 0
Any of the above321322
  • a There were five subjects in each treatment group.

  • b It should be noted that one subject in each group experienced two episodes of the specified complaint (after different inoculations).

  • c This subject experienced three episodes of the specified complaint (after different inoculations).