Table 3.

Local reactions occurring within 7 days following administration of each dose of C. difficile toxoid vaccine, by dose and formulationa

ReactionNo. of subjectsbwho received:
6.25 μg of toxoid25 μg of toxoid100 μg of toxoid
ToxoidToxoid-alumToxoidToxoid-alumToxoidToxoid-alum
Pain052515
Swelling000114
Erythema000133
Heat000000
Any local reaction052535
  • a The reactions were solicited in a systematic fashion. In addition, six of the subjects spontaneously reported pruritus at the injection site after receiving either 6.25 μg of toxoid (two subjects), 25 μg of toxoid-alum (two subjects), 100 μg of toxoid (one subject), or 100 μg of toxoid-alum (one subject).

  • b There were five subjects per treatment group.