Table 3.

Summary of the invasion and replication phenotypes of the STMs in amoeba and PBMC-derived macrophages

Mutant strainInvasion defectaReplication defect
BYEα-MOPS (amoeba)BYEα-ACES (multiple cell types)cA. castellaniiH. vermiformisPBMC-derived macrophages
STM-1+
STM-2+++
STM-3+b ++++
STM-4+
STM-5+++
STM-6++++
  • a Tenfold or greater difference from wild type.

  • b Acanthamoeba castellanii only.

  • c The cell types tested were A. castellanii, H. vermiformis, and PBMC-derived macrophages.