Table 4.

Circulating levels of IL-12 induced by ODN administration

TreatmentDay post challengeaCirculating IL-12 (pg/ml)Mean (pg/ml) of circulating IL-12
CpG ODN 1826210,08713,914
112,214
010,523
122,831
Control ODN 198221,4841,367
21,538
01,181
11,264
Infectivity control1105389
1418
1168
1863
  • a CpG ODN (50 μg) was administered i.m. in the tibialis anterior muscle on day −2 relative to i.v. inoculation of sporozoites on day 0. Serum was collected from individual mice on the day indicated, relative to i.v. inoculation of sporozoites on day 0, and assayed for IL-12 level by enzyme-linked immunosorbent assay.