Table 2.

Dose of CpG ODN 1826 required for protective immunity

ODNDose of ODN (μg)Day of ODN administrationaNo. infected/ total% ProtectionPvalueb
182650−20/101000.000008
100−72/10800.0007
50−75/10500.033
10−77/10300.211
3−77/10300.999
1982100−710/100
50−710/100
10−710/100
3−78/1020
None06/60
  • a CpG ODN was administered i.m. in the tibialis anterior muscle on the day indicated relative to i.v. inoculation of sporozoites on day 0.

  • b P values were calculated by comparing protection induced by CpG ODN 1826 treatment versus control ODN 1982 treatment, for each concentration of ODN, using the chi-square test (uncorrected) or Fisher's exact test (two-tailed) (if the expected cell value was less than five). P values of <0.05 were considered significant.