Table 1.

Median LD50 of R. australis in wild-type C57BL/6 and MHC-I, IFN-γ, and perforin gene knockout mice

Strain of miceDilution of R. australisNo. of survivors/ total no. of miceLD50 (PFU/mouse)
MHC-I KOa10−50/610−6.34 (0.5)
10−64/10
10−78/10
10−87/7
IFN-γ KO10−30/1010−3.71 (195)
10−47/10
10−510/10
Perforin KO10−30/810−4.51 (31)
10−41/7
10−55/6
Wild-type C57BL/610−13/1010−1.44 (3.6 × 104)
10−28/10
10−310/10
  • a KO, knockout.