Table 1.

CpG ODN 1828 induces protective immunity against sporozoite challenge

TreatmentDay of ODN administrationaNo. infected/ total% ProtectionPvalueb
CpG ODN 1826−74/10600.005
−20/101000.000008
−10/101000.000008
010/1000.999
Control ODN 1982−210/100
None18/180
  • a CpG ODN (50 μg) was administered i.m. in the tibialis anterior muscle on the day indicated relative to i.v. inoculation of sporozoites on day 0.

  • b P values were calculated by comparing protection induced by CpG ODN 1826 treatment versus control ODN 1982 treatment on each of days −7, −2, −1, and 0 relative to sporozoite challenge on day 0, using the chi-square test (uncorrected) or Fisher's exact test (two-tailed) (if the expected cell value was less than five). P values of <0.05 were considered significant.