Table 2.

Effects of PTK inhibitors on C. burnetiiphagocytosisa

C. burnetiiPhagocytosis index (mean ± SE (n = 3)
No pretreatmentLavendustin APP1
Virulent (200:1)130 ± 37287 ± 29b262 ± 41b
Avirulent
 200:1479 ± 69422 ± 35454 ± 51
 50:1218 ± 91180 ± 19195 ± 25
  • a THP-1 cells were pretreated with 10 μM lavendustin or PP1 for 30 min before stimulation with C. burnetii at the bacterium-to-cell ratios indicated for 2 h at 37°C. Bacterial phagocytosis with determined by indirect immunofluorescence.

  • b P < 0.02.