Table 5.

Protection of immunized guinea pigs against conjunctivitis following challenge with wild-type S. flexneri 2a

Immunization regimenNo. of guinea pigs challengedNo. of guinea pigs exhibiting severe keratoconjunctivitisa
CVD 120450
CVD 1204(pGA1-CS3)50
CVD 1204(pGA1-CS2)50
CVD 1204(pGA1-CS3) plus CVD 1204(pGA1-CS2)50
E. coli HS1515
  • a CVD 1204 versus HS, P = 0.000004 ; CVD 1204(pGA1-CS3) versus HS, P = 0.000064 ; CVD 1204(pGA1-CS2) versus HS, P = 0.000064 ; CVD 1204(pGA1-CS3) plus CVD 1204(pGA1-CS2) versus HS, P = 0.000064 .