Table 3.

Reactivity of antisera with whole cells of meningococci determined by immunofluorescencea

FormulationImmunofluorescence reactivityb on whole cells
MC58 Opc++MC139 Opc++MC139 Opc+H44/76 Opc+MC114 Opc
Opc+Al(OH)3
Opc-liposomes+−/+
Opc+MPLA-liposomes+++−/+
Opc-liposomes+MPLA-liposomes+++−/+
Opc-Zwit+++/−−/+
Opc+MPLA-Zwit+++−/+
Liposomes (empty)
MPLA-liposomes (empty)
Normal mouse serum
  • a Antisera were reacted with whole cells of the homologous and heterologous strains. Strains MC58 and H44/76 expressed the homologous Opc protein, and strain MC139 expressed a heterologous protein. The five patterns of reactivity observed are illustrated in Fig. 2.

  • b Symbols are defined in the legend to Fig.2.