Table 4.

Histopathology in rabbit skin following i.d. challenge of infection-immune rabbits with B. burgdorferi

Cell typeImmunohistochemical staining at (h p.i.)a:
2 (5/5)12 (5/5)24 (2/5)36 (2/5)48 (0/5)72 (0/5)96 (0/5)
B. burgdorferi +b +b +, +/−b
B lymphocytes
T lymphocytes
CD11b+cells+c ++c,d ++c +/−d +/−d
  • a The number of skin-culture-positive rabbits per total number of animals observed is indicated in parentheses. Observations made for four rabbits: −, none; +/−, few/some; +, moderate; ++, numerous.

  • b No intact organisms were detected, but onlyB. burgdorferi antigen (Compare Fig. 4d to Fig. 3d).

  • c PMNs as determined by microscopic analysis of H&E-stained serial sections.

  • d Macrophages as determined by microscopic analysis of H&E-stained serial sections.