Histopathology in B. burgdorferi-infected rabbit skin during disease progession and development of immunity
| Cell type | Immunohistochemical staining at (wk p.i.)a | ||
|---|---|---|---|
| 3 (16/20) | 13 (0/20) | 24 (0/20) | |
| B. burgdorferi | +/− | − | +/−b |
| B lymphocytes | +, +/− | − | − |
| T lymphocytes | +/− | − | − |
| CD11b+cells | +/−c | +/−c | − |
↵a The number of skin-culture-positive rabbits per total number of animals observed is indicated in parentheses. Observations were made for two rabbits: −, none; +/−, few/some; +, moderate; ++, numerous.
↵b Detection of only B. burgdorferi antigen.
↵c Macrophages as determined by microscopic analysis of H&E-stained serial sections.