Table 2.

Cytokine levels in BAL fluid

CytokineMean cytokine concna (pg/ml of BAL fluid) for mice of indicated genotypeb ± SEM after treatment with:
PBSBC7
+/+−/−+/+−/−
TNF-α4.3 ± 2.34.2 ± 1.413.1 ± 5.210.9 ± 1.3
IFN-γ30.5 ± 9.620.7 ± 30.150.4 ± 22.547 ± 5.5
KC203 ± 100190 ± 118250 ± 76666 ± 194
MIP-280 ± 4090 ± 24342 ± 66∗∗ 326 ± 60∗∗
  • a Statistical analysis was by unpairedt test. ∗, P = 0.02 forCftr −/− mice versusCftr +/+ mice treated with BC7 and forCftr −/− mice treated with BC7 versusCftr −/− mice treated with PBS; ∗∗, P = 0.02 for Cftr −/− mice versus Cftr −/− mice treated with PBS; ∗∗∗, P = 0.005 for Cftr +/+mice versus Cftr +/+ mice treated with BC7.

  • b +/+, Cftr +/+; −/−,Cftr −/−. n = four to six mice for each group.