Table 1.

Mycobacterial multiplication in unvaccinated and vaccinated B6 mice infected by 3 × 104 or 105 M. ulcerans strain 5150 AFB

VaccineInfection with 3 × 104M. ulcerans AFBInfection with 105M. ulcerans AFB
No. of AFB/mlaΔLog10bPvaluecNo. of AFB/mlaΔLog10bNo. of CFU/mlaΔLog10bPvaluec
NoneNDd 6.16 ± 0.28 (7)5.99 ± 0.26 (7)
Control DNA5.95 ± 0.55 (4)5.85 ± 0.25 (6)5.63 ± 0.45 (6)
M. bovisBCG4.60 ± 0.35 (6)1.35<0.0054.00 ± 0.02 (7)1.854.21 ± 0.14 (7)1.42<0.005
Ag85A DNA4.29 ± 0.42 (5)1.66<0.0054.71 ± 0.67 (7)1.144.52 ± 0.30 (7)1.11<0.005
  • a Mean ± SD of CFU or AFB per milliliter, expressed in log10. The number of mice per group is in parentheses.

  • b ΔLog10, difference compared to mice vaccinated with control DNA.

  • c Each P value shown reflects a comparison with the mean log10 value for control DNA-treated mice infected with M. ulcerans.

  • d ND, not done.