Table 5.

Recovery of iron transport mutants of CFT073 from the kidneys of infected mice

Strain Phenotype Infectivity rateaNo. of CFU/g of kidneyb
Trial 1
 CFT073Wild type 9/95.6 × 103 (1.1 × 102–6.7 × 104)
 CFT073-IUC Iuc 8/103.5 × 104 (2.1 × 102–1.8 × 105)
Trial 2
 CFT073 Wild type 5/71.2 × 104 (1.1 × 103–5.6 × 104)
 CFT073-LH ChuA 6/92.8 × 104 (1.4 × 102–7.0 × 104)
Trial 3
 CFT073 Wild type 13/143.8 × 104 c (7.0 × 102–1.4 × 105)
 CFT073-ENT Ent 14/144.1 × 103 (2.1 × 102–9.2 × 104)
 CFT073-IUC/ENT Iuc Ent 13/171.1 × 103 c (2.8 × 102–4.7 × 104)
  • a Number of animals with positive kidney cultures/number of animals inoculated.

  • b Median (range) of the number of CFU/g for all animals with positive cultures.

  • c P = 0.02 (Mann-Whitney); for all other comparisons, P > 0.05 .