Table 6.

Mouse competition assay with CFT073 and its isogenic iron utilization strains

CFT073 vs.:No. of miceCompetitive indexa
Bladders Kidneys
CFT073-ENT/IUC 6b 0.90 ± 0.38c 1.11 ± 0.52c
CFT073-IUT7d 0.008 ± 0.06e 0
CFT073-LH 7d 0.026 ± 0.003e 0.058 ± 0.006c
  • a Competitive index is the ratio of output mutant to wild-type bacteria (recovered from the bladder or kidney) divided by the ratio of input mutant to wild-type bacteria (inoculated into the mouse). A competitive index of <1 indicates that the strain was recovered in lower numbers relative to the wild type.

  • b Bacteria were not recovered from the kidneys of two of the mice.

  • c P ≥ 0.1 .

  • d Bacteria were not recovered from the kidneys of one of the mice.

  • e P < .001 .