Table 1.

Chemokines analyzed in this studya

ChemokineInducer(s)Receptor(s)Principal target(s)
CXC
 KC (CXCL1-3)b LPS, IL-1, TNF-α, PDGFCXCR2N
 MIP-2 (CXCL1-3)LPS, IL-1, TNF-αCXCR2N
 LIX (CXCL5)LPSCXCR2N
 Mig (CXCL9)IFN-γCXCR3T, NK, B
 CRG-2/IP-10 (CXCL10)IFN-α, -β, -γ, LPS, IL-1, TNF-αCXCR3T, NK, B
 SDF-1 (CXCL12)ConstitutiveCXCR4T, B, D, M, Thy
CC
 TCA3/I-309 (CCL1)LPS, IL-1CCR8T, M, Thy
 JE/MCP-1 (CCL2)LPS, IL-1, TNF-α, IL-4, thrombin, IFN-γ, PDGF, GM-CSF, M-CSFCCR2M, T, NK, Ba, B
 MIP-1α (CCL3)LPS, IL-1, TNF-α, IFN-γ, TCR, FCɛRCCR1, CCR5T, M, N, D, E, Ba, NK, B, Thy
 MIP-1β (CCL4)LPS, IL-1, TNF-α, TCR, BCRCCR5T, M, D, Thy
 RANTES (CCL5)LPS, IL-1, TNF-α, IFN-γCCR1, CCR3, CCR5T, M, E, Ba, D, NK, N, B, Thy
 MCP-3/FIC (CCL7)LPS, IL-1, TNF-α, IFN-γ, PDGFCCR1, CCR2, CCR3M, T, E, Ba, D, NK, Thy
 MIP-1γ (CCL9)ConstitutiveCCR1N, T
 Eotaxin (CCL11)IL-1, TNF-α, IL-4, IL-13, IFN-γCCR3E, Ba, T
 MCP-5 (CCL12)LPS, IFN-γCCR2M, T, B
C, lymphotactin (XCL1)IL-4, TGF-β, TCRXCR1T, NK
  • a Abbreviations: N, neutrophil; B, B lymphocyte; Ba, basophil; D, dendritic cell; E, eosinophil; M, monocyte; NK, natural killer cell; T, T lymphocyte; Thy, thymocyte; BCR, B-cell receptor; TCR, T-cell receptor; FCɛR, immunoglobulin E Fc receptor; PDGF, platelet-derived growth factor; GM-CSF, granulocyte-macrophage colony-stimulating factor.

  • b Systematic names are in parentheses beside common names. There are occasional ambiguities in applying the systematic names for human chemokines to their presumed mouse orthologues.