Table 3.

Association of chemokines with type 1 and type 2 responses in murine models using S. mansonia

ChemokinePrimary embolization modelSecondary embolization modelInfection model
CXC
 KC (CXCL 1-3)NDb Type 1/type 2ND
 MIP-2 (CXCL 1-3)Type 1NIc Type 1
 LIX (CXCL5)NDNIND
 Mig (CXCL9)NDType 1ND
 CRG-2/IP-10 (CXCL10)Type 1Type 1Type 1
 SDF-1 (CXCL12)NDNIND
CC
 TCA3/I-309 (CCL1)Type 2Type 2Type 1/type 2
 JE/MCP-1 (CCL2)Type 1Type 1/type 2Type 1
 MIP-1α (CCL3)Type 2Type 2Type 1/type 2
 MIP-1β (CCL4)Type 1Type 1/type 2Type 1
 RANTES (CCL5)Type 1Type 1Type 1
 MCP (CCL7)NDType 1/type 2ND
 MIP-1γ (CCL9)NDType 2ND
 Eotaxin (CCL11)Type 2Type 2Type 1/type 2
 MCP-5 (CCL12)NDType 1/type 2ND
C, lymphotactin (XCL1)Type 1Type 1Type 1
  • a Responses are type 1 or type 2 as labeled. Type 1/type 2, induced but not polarized.

  • b ND, not determined.

  • c NI, not induced.