Table 3.

Peak proliferation and peak cytokine production by PBMC in response to various antigens after immunization with CVD 1207, by dose

Dose groupAntigenaResponse (no. responding/total)
ProliferationIL-2IL-4IL-5IFN-γIL-10IL-12IL-15TGF-β
109 CFUSF homogenate1/70/80/40/41/81/80/30/31/1
SF particulate0/70/80/40/41/81/80/30/30/1
IpaC0/60/70/40/40/81/80/30/31/1
IpaD1/60/70/40/41/81/80/40/40/1
1010 CFUSF homogenate0/3NDb 0/3ND0/30/3NDND0/3
SF particulate1/3ND0/3ND0/30/3NDND0/3
IpaC0/3ND0/3ND0/30/3NDND0/3
IpaD1/3ND0/3ND0/30/3NDND2/3
  • a SF, S. flexneri.

  • b ND, not done.