Table 1.

Production of IFN-γ, IL-4, and IL-10 in the spleen cell cultures obtained from S. aureus-infected micea

Time postinfection and infection statusCytokine titerb
IFN-γ (ng/ml)IL-4 (pg/ml)IL-10 (ng/ml)
7 days
 Uninfected59.8 ± 3.243 ± 0.414.5 ± 3.0
 Infected7.7 ± 0.2c41 ± 2.532.5 ± 2.3c
21 days
 Uninfected34.6 ± 2.291 ± 10.328.2 ± 1.3
 Infected17.9 ± 1.9c143 ± 13.5c42.7 ± 6.2c
  • a Mice were infected with 107CFU of S. aureus or left uninfected.

  • b Spleen cells were stimulated with heat-killedS. aureus for 48 h, and the cytokine titer in each culture supernatant was determined. Each result represents the mean ± standard deviation for a group of four mice. The results were reproduced in three repeated experiments.

  • c Significantly different from the value for the uninfected group (P < 0.01).