Table 1.

Cytokine mRNA expression by individual classes of human PBLs in response to the HGE agent or rP44

Donor no.Composition of PBLsaCytokine mRNA inductionb
NeutrophilsLymphocytesMonocytesEosinophilsIL-1βTNF-αIL-6IL-10IFN-γIL-2IL-8TGF-βc
163.8 ± 0.929.4 ± 0.46.1 ± 0.60.7 ± 0.2+++
266.2 ± 0.724.5 ± 0.58.3 ± 0.71.0 ± 0.2+++++
365.2 ± 0.427.3 ± 0.46.6 ± 0.90.9 ± 0.1++++
464.8 ± 0.527.2 ± 0.66.9 ± 0.81.1 ± 0.2++++
561.1 ± 0.630.2 ± 0.47.8 ± 0.40.9 ± 0.2++++NDND
662.9 ± 1.128.9 ± 1.27.4 ± 1.00.8 ± 0.1+++NDNDNDNDND
  • a Values are mean percentages ± standard deviations of data from three slides.

  • b +, induced; −, not induced; ND, not done.

  • c Constitutively expressed.