TABLE 1

Applications of controlled human malaria infection

ApplicationReference(s)
Drug evaluation
    Sporozoite challenge12, 92106
    Blood-stage challenge911, 95, 96, 98103, 105114a
Vaccine evaluation
    P. falciparum preerythrocytic vaccine candidate
        Sporozoite challenge18, 20, 3638, 40, 42, 79, 80, 115151
        Blood-stage challenge115
    P. falciparum blood-stage vaccine candidate
        Sporozoite challenge14, 20 36, 42, 125, 126, 131, 145, 146, 151
        Blood-stage challenge13, 16, 19
    P. vivax preerythrocytic vaccine candidate
        Sporozoite challenge15, 17, 37, 149
        Blood-stage challengeNot applicable
Immunization strategy
    Chemoprophylaxis and sporozoites7, 8, 4951, 81, 152
    Blood-stage infection and drug treatment6
Parasite diagnostics21, 22
Parasite biology153
    Factors influencing virulence2325, 154156
    Disease processes26, 157159
Human immune response2732, 84, 86, 160209
  • a Studies registered on the Australian New Zealand Clinical Trials Registry but not yet published: ACTRN12617000244303 and ACTRN12614000781640.