Table 3.

ASC response to CTB and fimbrial antigens of two lots of ETEC vaccinea

AntigenResponsea
ETEC lot E003ETEC lot E005
After dose 1After dose 2After dose 1After dose 2
Frequency (%)GM no. of spotsFrequency (%)GM no. of spotsFrequency (%)GM no. of spotsFrequency (%)GM no. of spots
CTB19/21 (90)* 11.422/22 (100)* 38.711/13 (85)* 7.011/11 (100)* 51.3
CFA/I17/21 (81)* 13.311/22 (50)* 2.313/13 (100)* 17.19/11 (82)* 2.8
CS111/15 (73)* 5.77/22 (32)* 0.712/13 (92)* 17.39/11 (82)*!3.0
CS211/15 (73)* 2.07/22 (32)* 0.8NDNDNDND
CS48/15 (53)* 2.37/22 (32)* 0.3NDNDNDND
CS55/11 (45)* 2.04/13 (31)0.3NDNDNDND
  • *, significantly higher than the rate among placebo recipients (P < 0.01); !, significantly higher than the rate among recipients of the second dose of lot E003 (P = 0.01); ND, Not done.