Table 4.

Efficacy of CVD 908-htrA and CVD 909 in protecting mice against intraperitoneal challenge with wild-type serovar Typhi suspended in hog gastric mucin, 4 weeks after a single i.n. immunization

Strain or controlMortalitya (%)% Vaccine efficacy
CVD 908-htrA 9/10 a (90)10
CVD 909b 3/8 b (38)62
PBS10/10 c (100)0
  • a Number of mice that died per total number tested. a versus c, P = 0.0043, Fisher's exact test; b versus c, P = 0.0065, Fisher's exact test.

  • b Two mice allocated to this group died during handling prior to challenge.