Table 3.

Serum O and Vi antibody responses in mice immunized with a single i.n. dose of CVD 908-htrA or CVD 909a

Strain or controlSerum IgG anti-ViSerum IgG anti-O
Day 0 GMTDay 23 GMT (range)Frequency of seroconversionb (%)Day 0 GMTDay 23 GMT (range)Frequency of seroconversion (%)b,c
CVD 908-htrA 1049 a (20–160)9/10 b (90)3187 (20–320)3/6 (50)
CVD 90910160 d (80–640)10/10 e (100)3280 (20–160)4/9 (44)
PBS10100/10 f (0)2625 (20–40)0/7 (0)
  • a a versus d, P = 0.0007, Mann-Whitney test; b versus f, P < 0.001, Fisher's exact test; e versus f, P < 0.0001, Fisher's exact test.

  • b Number of mice which seroconverted per total number tested.

  • c Some mice had insufficient quantities of serum remaining for testing O antibody.