Table 6.

Protective ability of SPE A mutants against challenge with wild-type SPE Aa

Immunizing agentNo. of animals with feverb/totalNo. dead/totalPc
None9/1010/10
N20D/C98S0/50/50.004
N20D/D45N/C98S1/50/50.004
Q19H/N20D/L41A/L42A/D45N/C98S0/50/50.004
  • a Miniosmotic pumps were loaded with 500 μg of wild-type SPE A.

  • b Rectal temperatures were taken at before miniosmotic pump implantation (baseline) and on day 2. Fevers were considered significant if temperatures were greater than 0.5°C above baseline.

  • c By Fisher's exact test for nonimmunized compared to immunized animals.