TABLE 1.

GMCs of serum IgG antibodies to pneumococcal capsular PSs in infants immunized with a 7-valent pneumococcal conjugate vaccine or control vaccine at 2, 4, and 6 months of age and boosted with a homologous vaccine at 12 months of age

SerotypeVaccineGMC [μg/ml (95% CI)] in infants at age (mo):
2 (n = 52-58)7 (n = 53-55)12 (n = 52-56)13 (n = 46-55)24 (n = 44-54)
4PncCRM0.12 (0.09-0.17)1.71 (1.32-2.20)0.42 (0.34-0.53)2.55 (1.99-3.27)0.50 (0.40-0.62)
PncOMPC0.17 (0.13-0.24)2.74 (1.92-3.91)1.12 (0.85-1.48)4.63 (3.09-6.95)1.11 (0.85-1.45)
Control0.10 (0.08-0.14)0.05 (0.04-0.07)0.09 (0.07-0.12)0.11 (0.08-0.14)0.19 (0.15-0.25)
6BPncCRM0.21 (0.15-0.30)1.99 (1.35-2.95)0.92 (0.64-1.32)9.02 (6.48-12.54)1.48 (1.11-1.99)
PncOMPC0.26 (0.18-0.36)0.40 (0.29-0.54)0.50 (0.37-0.67)1.76 (1.15-2.67)0.95 (0.65-1.39)
Control0.16 (0.11-0.22)0.09 (0.07-0.12)0.13 (0.10-0.18)0.15 (0.12-0.20)0.25 (0.19-0.32)
9VPncCRM0.26 (0.19-0.35)2.47 (1.97-3.11)0.81 (0.66-1.00)3.97 (3.20-4.91)0.87 (0.67-1.12)
PncOMPC0.24 (0.18-0.33)1.98 (1.55-2.54)1.03 (0.8-1.33)4.05 (3.14-5.22)1.21 (0.87-1.69)
Control0.20 (0.15-0.27)0.10 (0.07-0.13)0.17 (0.13-0.23)0.21 (0.16-0.27)0.33 (0.25-0.45)
14PncCRM0.28 (0.19-0.41)6.26 (4.77-8.20)2.63 (2.12-3.26)10.80 (8.29-14.06)1.86 (1.47-2.36)
PncOMPC0.38 (0.26-0.56)2.96 (2.05-4.25)1.25 (0.93-1.68)5.31 (3.68-7.66)1.50 (1.06-2.13)
Control0.46 (0.31-0.68)0.21 (0.16-0.27)0.19 (0.15-0.24)0.21 (0.17-0.27)0.28 (0.21-0.37)
18CPncCRM0.16 (0.11-0.23)3.55 (2.80-4.49)0.88 (0.73-1.07)6.51 (5.04-8.42)0.99 (0.77-1.28)
PncOMPC0.21 (0.15-0.30)1.03 (0.76-1.40)0.56 (0.44-0.72)3.06 (2.27-4.12)0.70 (0.51-0.97)
Control0.24 (0.16-0.34)0.08 (0.06-0.11)0.09 (0.07-0.11)0.10 (0.08-0.13)0.20 (0.13-0.29)
19FPncCRM0.42 (0.30-0.60)3.28 (2.56-4.20)0.86 (0.65-1.13)4.96 (3.86-6.36)2.14 (1.47-3.12)
PncOMPC0.54 (0.39-0.75)3.54 (2.74-4.57)2.37 (1.65-3.40)8.58 (6.10-12.08)4.80 (2.95-7.82)
Control0.37 (0.26-0.52)0.22 (0.17-0.29)0.34 (0.24-0.46)0.40 (0.31-0.53)0.62 (0.47-0.82)
23FPncCRM0.19 (0.13-0.28)2.51 (1.84-3.43)0.79 (0.59-1.05)6.20 (4.51-8.52)1.28 (0.98-1.68)
PncOMPC0.32 (0.23-0.45)0.62 (0.46-0.82)0.64 (0.47-0.86)2.14 (1.54-2.99)1.05 (0.76-1.44)
Control0.18 (0.13-0.25)0.10 (0.07-0.12)0.13 (0.10-0.18)0.15 (0.12-0.20)0.23 (0.17-0.31)